Christina Applegate Leaves NBC's Up All Night

Christina Applegate is departing her NBC comedy, “Up All Night.”

“It’s been a great experience working on ‘Up All Night’, but the show has taken a different creative direction and I decided it was best for me to move on to other endeavors,” Christina said in a statement on Friday. “Working with Lorne Michaels has been a dream come true and I am grateful he brought me into his TV family. I will miss the cast, producers and crew, and wish them the best always.”

In Season 1 of the show, Christina played working mom Reagan Brinkley, who was a producer on a fictional talk show – “Ava” – hosted by Maya Rudolph’s character. Season 2 changed things up with Maya’s character now a former talk show host, and Christina’s Reagan adjusting to being a stay-at-home mom.

The comedy also stars Will Arnett as Reagan’s husband, Chris.

NBC would not comment on the news, when contacted by Access Hollywood on Friday.

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