Seth MacFarlane & Charlize Theron's Wild 'West' Chemistry

Seth MacFarlane & Charlize Theron's Wild 'West' Chemistry

Seth MacFarlane is finally stepping in front of the camera for his new comedy, “A Million Ways to Die in the West.” And, for his first leading role he chose Charlize Theron to be his leading lady! Watch as the two explain how comfortable they are working with one another.

lease to be his leading lady. Starring in the first feature film. You have most gorgeous woman in Hollywood and get to make out with her. It's uncomfortable I'm right here. I'm about ready to shoot this. Keep moving. Still recovering from the experience. Listen. A lot of baggage. It does when you already have a bruised what are you talking Ba lot of. That a lot of that. Sort of many times before but it is this is exactly who you want to be partner with if you are a vir general at this sort of thing. Wow! You look amazing. I really love the most alluring fashion today is this fat ass. This is the meanest trick to play on me. Prairie girl look treats her fine and Seth western spoof a million way to die in the west. American west is a terrible place in time. Everything else not you wants to kill you. The people. Hungry animal. Out law. The doctor. She had a splinter. Reporter: Oscar winning actress and mcfar land and agent got comfortable with each other quickly on the set. Somebody of her caliber and talent, it made it 1,000 times easier for me to get comfortable with a part of this process I hadn't really done that much of. Less pressure having to good in the kissing scene. When you are with when you are with an Oscar winner, you know, if you are in good haichbilitydz you are what? You are what. You are you are you are. Guaranteed good kissing is that it. You are guarantee. If please don't schett shoot us. Reporter: They manage to assemble quite a cast and Sarah Silverman as quirkie couple. You guy have amazing chemistry. Did you know it from the giddy up. You are hilarious. Sarah is incredible. And awesome. I'm a huge fan beforehand and so I just love her. You are both such natural. I love you too. The. What's with the hair. Every year people die. Everybody hold still. People die at the fair people die at the fair.